Inhibits RNA polymerase
Activates PXR
C43H58N4O12
MW 823.0 Cas No. 13292-46-1
Store at 0-5°C
Rifampicin is a semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Rifampim is a Rifamycin Antibacterial. The chemical classification of rifampin is Rifamycins.
(FDA Pharmacology Summary fro FDA Pharm Classes)
Rifampin is a semisynthetic derivative of rifamycinwith broad antibacterial activity. Rifampin inhibits DNA-dependent RNA polymerase in susceptible bacteria and is often used in combination with other antibiotics for various infections including tuberculosis. (Pharmacology from NClt)