C11H12Cl2N2O5
MW 323.1 CAS 56-75-7
Store at room temperature
Applications:
Produced by Streptomyces venezuelae, a potent inhibitor of protein synthesis.
Use with Gram-negative/Gram-positive bacteria.
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Chloramphenicol is an antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106). from MeSH.
Chloramphenicol is an Amphenicol-class Antibacterial. The chemical classification of chloramphenicol is Amphenicols. (FDA Pharmacology Summary from FDA Pharm Classes.)
Chloramphenicol is a semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation. (Pharmacology from NCIt)